pilipili漫画

Dr. Vahid Adibnia -
adibnia@dal.ca
Assistant Professor of Chemistry 鈥� Cross-appointed from Biomedical Engineering and Dentistry

Winter 2024 internship positions (6 hrs/week minimum, starting January) are also available on these projects (and other projects) for students who would like to start working on their projects earlier than this summer. Contact Dr. Adibnia for more information.

Project 1. Biosourced injectable lubricating hydrogels for treatment of osteoarthritis
Osteoarthritis (OA) is a progressive musculoskeletal disorder and is the most dominant cause of adult disability in the world. Currently, 1 in 5 Canadians is diagnosed with OA and this number is expected to increase by 50% by year 2040, if no action is taken to prevent the current trend. In addition to experiencing pain and reduced mobility, OA patients are twice more likely to develop mental health problems and be out of the workforce. Therefore, developing new treatments that can delay cartilage degradation in OA patients is of significant importance for Canadians.

In this project, we design and synthesize lubricating hydrogels from biosourced polymers that can protect cartilage against frictional wear in biologically relevant conditions using well-established cartilage degradation models. Results of this project will improve our understanding about the process of biolubrication in human joints.

The pilipili漫画ful USRA student will gain skills in:
Chemical modification, characterization and purification of biosourced polymers. Various polymer crosslinking approaches. Analyzing mechanical properties of biomaterials. Quantifying interactions of hydrogels with biological samples such as cartilage and cells. Collaborative and interdisciplinary research.

Project 2. Biosourced antifouling coatings for the marine industry
Marine biofouling, the process by which marine organisms attach to underwater structures, represents a major economic burden for maritime industries. Biofouling also has detrimental consequences on port and fishery infrastructures for example, by severely clogging circulation piping. Strategies to prevent biofouling are thus a key challenge.

In this project, we take inspiration from nature in designing efficient antifouling active molecules and macromolecules that can be added to currently available coatings in order to significantly improve their efficacy.

The pilipili漫画ful USRA student will gain skills in:
Chemical modification, characterization and purification of small antifouling molecules. Surface coating and testing antifouling performance at the nanoscale using precise techniques such as QCM-D, SFA, etc. Integration of antifouling coatings with currently available marine coatings (in collaboration with an industrial partner). Collaborative and interdisciplinary research.

Project 3. Biosourced and bioactive nanofibers for tissue engineering
Biological tissues are predominantly anisotropic structures made of macromolecular fibers. Replicating the structure of these tissues in the laboratory using biosourced and bioactive polymers is a valuable attempt for creating soft materials with applications in dentistry, 3D printing and microfluidics.

In this project, primarily using a high throughput centrifugal spinning approach for producing nanofibers, we design and test innovative nanofibers that show strong cell attachment and cell guidance, tunable surface chemistry, and physiologically relevant mechanical properties.

The pilipili漫画ful USRA student will gain skills in:
Chemical modification, characterization and purification of biosourced polymers as building blocks of nanofibers. Nanofiber fabrication using various techniques including electrospinning, centrifugal spinning and contact drawing. Nanomaterials imaging and characterization. Cell-materials interactions. Collaborative and interdisciplinary research.

Dr. Heather Andreas听 -听听Andreas Lab Website
heather.andreas@dal.ca
Associate听Professor of Chemistry

Increasing Charge Storage on Carbon Supercapacitors
Supercapacitors are environmentally friendly energy storage devices that can store the energy produced by solar panels and windmills.听This project will explore chemical and electrochemical methods of increasing the amount of energy that can be stored on carbon electrodes in aqueous solutions.听These systems will also be characterized by spectroscopy and microscopy.

The pilipili漫画ful USRA student will gain skills in:
electrochemical methods, including supercapacitor/battery testing procedures; spectroscopic analysis of carbon surface functionalities (UV-Vis, Raman and X-ray Photoelectron Spectroscopy); wet chemical methods of changing the surface functionalities on carbon; a range of surface characterization techniques, including surface area measurements, and surface imaging techniques.

Dr. Alex Baker听 -听
alexander.baker@dal.ca
Assistant Professor of Chemistry

Functional Biopolymers as Hydrogels and Adhesives
Hydrogels are versatile water-swollen polymeric networks that have versatile function for a variety of chemical, medical, and agricultural applications. We are focused on discovering chemical crosslinking reactions compatible with mild aqueous environments for applications such as enzyme tethering, cell encapsulation, and therapeutic delivery. Oxime chemistry utilizes ketone or aldehyde groups that react withoxyamines, producing water as a听byproduct. Our aim is to synthesize polymers to study the effects of gelation rate and hydrogel stability. Additionally, we employ synthetic chemistry and synthetic biology to selectively immobilize proteins within hydrogel networks to facilitate surface adhesion or preserve enzymatic activity. This project involves small molecule and polymer synthesis, protein expression, and characterization of hybrid materials.

The pilipili漫画ful USRA student will gain skills in:
Organic synthesis, protein chemistry, and synthetic biology. Techniques not limited to chemical synthesis, small molecule purification, structural characterization, nuclear magnetic resonance spectroscopy, recombinant protein expression, flash chromatography, and gel electrophoresis.

Dr. Stephen Bearne听 -听
sbearne@dal.ca
Professor - Cross-appointed from Biochemistry听& Molecular Biology

Synthesis & Study of Inhibitors Targeting Enzymes of Therapeutic Interest
We are pursuing the synthesis of specific compounds for use in several enzymology projects: (i) transition state analogues for insertion into enzyme active sites to probe the role of binding determinants in catalysis; (ii) amino acid analogues as inhibitors of racemases; and (iii) purine analogues as enzyme-specific labels. 听The interaction of these novel compounds with specific enzymes will be studied using a variety of assay techniques.

The pilipili漫画ful USRA student will gain skills in:
Organic synthesis and protein chemistry, physical organic chemistry laboratory techniques, enzyme kinetics, molecular biology & microbiology techniques, methods of protein purification and characterization, and spectroscopy (NMR, CD, UV)

Dr. Carlie Charron
carlie.charron@dal.ca
Assistant Professor of Chemistry

Stabilizing Peptide Nanotube Architectures using Amino Acid Side Chains
Cyclic peptide nanotubes are an organic alternative to the carbon nanotube possessing characteristics such as improved aqueous solubility, ample functionalization potential, and low听in vivo听toxicity. They鈥檙e composed of cyclic peptides that adopt a flat ring conformation allowing them to stack on top of one another using hydrogen bonding into a tube-like architecture. This project aims to remove the structural reliance on hydrogen bonds by installing a covalent linkage between neighbouring cyclic peptides by utilizing amino acid side chain functionality.

The pilipili漫画ful USRA student will gain skills in:
Solid phase peptide synthesis, post synthetic peptide modification, high performance liquid chromatography, transmission electron microscopy, dynamic light scattering

Dr. Saurabh S. Chitnis -
saurabh.chitnis@dal.ca
Assistant听Professor of Chemistry

1. Cationic Nanobubbles: Making and Studying Liquids with Permanent Porous Cavities
This project will involve making and studying the properties of a new phase of dissolved material known as cationic nanobubbles. Such solutions have not been prepared before and their potential for application in dissolving, sensing, and separating different gases remains undiscovered. Their synthesis and properties assessment will be the main component of this project. Interested students will be exposed to a broad range of inorganic synthesis and spectroscopy techniques.

2. Cagey Polymers: Connecting Inorganic Cages to make Polymers
Most polymers contain a backbone of atoms or rings. The natural extension of this pattern is preparing polymers that contain a backbone of interconnected cages. Yet such materials have not been prepared before. The inorganic elements readily form molecular cages and participate in coordination chemistry. This project will involve the preparation of inorganic cages and connecting them together to make polymers with a 3-dimensional bead-like backbone. The physical and electronic properties of such polymers will be studied to discover potential applications.

Dr. Jeff R. Dahn听 -听
jeff.dahn@dal.ca
Professor, Canada Research Chair and NSERC/TESLA Canada Co. Industrial Research Chair - Cross-appointed from Physics

Dr. Mita Dasog听 -听
mita.dasog@dal.ca
Assistant Professor of Chemistry

Project 1: Metal carbide and nitride nanoparticles for water-splitting application
This project will involve syntheses and characterization of metal carbide and nitride nanoparticles using solid-state chemistry. The nanoparticles will be characterized using various techniques including powder X-ray diffraction, transmission and scanning electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. The nanoparticles will be further tested as electrode materials for water splitting reactions.

The pilipili漫画ful USRA student will gain skills in:
Students will learn nanomaterials synthesis, solid-state chemistry, operation of various instruments and data analysis, electrochemistry, and communication skills.

Project 2: Metal oxide nanoparticle inks for transparent conducting electrodes
This project will focus on synthesis and surface functionalization of metal oxide nanoparticles. The nanoparticles will be characterized using various techniques including infrared spectroscopy, transmission and scanning electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. The nanoparticles will be coated into thin films and their opto-electronic properties will be investigated.

The pilipili漫画ful USRA student will gain skills in:
Students will learn nanomaterials synthesis, solid-state chemistry, operation of various instruments and data analysis, device fabrication, and communication skills.

Dr. Alan Doucette听 -听 Doucette Lab Website
alan.doucette@dal.ca
Professor of Chemistry

1. Protein purification, separation and analysis by mass spectrometry
There has been a recent explosion in the development of protein-based pharmaceuticals.听 Last year, over half of the new drugs approved by the FDA were antibody or peptide based compounds. 听Analytical chemists are in high demand in industry 鈥� particularly those with skills in advanced instrumentation such as liquid chromatography and mass spectrometry.

Our lab works in the field called proteomics, which deals with the large scale analysis of proteins from biological sources.听 We specialize in the development of improved analytical instruments and/or strategies to better characterize the samples.听 Mass spectrometry (MS) is our detector, but we need many more pieces to be in place.听 GELFrEE is a commercial device developed in my lab to separate proteins ahead of mass spectrometry (Google it to find out more!).

Right now, we鈥檙e working on a new strategy to purify proteins 鈥� a device we like to call Transmembrane Electrophoresis, or TME for short. TME uses electric fields to drive contaminants through a porous membrane, leaving the now clean proteins behind.听 Our prototype design has already proven incredibly effective, but we think a re-design of this instrument would allow it to work even better. In particular, we鈥檇 like to couple TME, + GELFrEE + MS.听 This all-in-one platform would have unprecedented ability to characterize proteins. But we can鈥檛 test it until we build it first.

The pilipili漫画ful USRA student will gain skills in:
Bioanalytical Chemistry/ Proteomics / Electrophoresis/ Mass Spectrometry / Instrument Design/ Engineering / Research Communication.听 Don鈥檛 worry if you don鈥檛 have experience with machining/ electronics.听 You鈥檒l have lots of help, and the whole point of this project is to learn new skills.

Dr. Michael S. Freund听 -听
michael.freund@dal.ca
Professor of Chemistry

1.听 Membranes for Artificial Photosynthetic Systems鈥�
Given the scale of projected energy needs as well as the rapid climate change associated with growing CO₂ levels in the atmosphere, there is a major push by governments to increase the rate of innovation and discovery in the area of carbon-neutral solar fuel production. 听For example, the US National Science Foundation has established a Solar Energy Initiative and the European Science Foundation has established the EuroSolarFuels program to support interdisciplinary efforts to address solar energy and solar fuels. 听The US Department of Energy has made major investments to establish facilities (e.g., http://solarfuelshub.org/) for testing and translating innovations in the field with a focus on scaling up and enabling. 听Our group, which includes collaborators in Electrical and Computer Engineering, is focusing on the development of membranes that will likely play a key role in artificial photosynthetic systems. 听This effort includes the design and synthesis of new materials as well as the study of their electronic properties and their integration with light absorbers and catalysts required for functional devices. 听Read our recent review to learn more about the topic.听 "Membranes for Artificial Photosynthesis" Energy Environ. Sci. (2017)

The pilipili漫画ful USRA student will gain skills in:
Electrochemistry, polymer science, semiconductors and catalysis.听 There are a wide range of opportunities to get involved in various aspects of this research.听听 听

2. Polymer-Based Electronics
The widespread focus on organic and molecular approaches to electronics has been driven by the promise that new mechanisms may overcome current limitations of silicon-based devices. 听In particular, silicon devices based on capacitive and field effects are dominated by interfacial processes that are currently limited by defects and scaling issues. 听However, molecular devices currently suffer from issues of reproducibility that are in part a result of the incorporation of organic materials into a fairly aggressive lithographic process. 听Our research program explores well-defined mechanisms for redox-driven memory and electronics based on field-driven ion motion. 听By designing molecular composite architectures that distribute charges within dopable systems we are opening up new approaches for the design of polymer-based electronics and memory. 听Working with collaborators in Electrical and Computer Engineering and industry we are working on producing functional memory based on these new principles.

The pilipili漫画ful USRA student will gain skills in:
Electrochemistry, electronic memory design and electronic testing.

3.听 Integrated Circuit, Chemical Sensor Arrays
The invention of the CCD chip has revolutionized the interface between technology and its environment. 听By pixilating optical images of its surroundings, devices can use sophisticated imaging processing and pattern recognition algorithms to perform increasingly sophisticated tasks associated with visual perception. 听The creation of a chemically diverse sensor array chip that mimics the olfactory system could provide the next revolution in sensory input for technology. 听In collaboration with groups in Electrical and Computer Engineering, we are working on CMOS circuitry design and new methods for creating large numbers of chemically diverse polymer sensing materials on the chips to significantly expand the ways in which technology interacts and functions.

The pilipili漫画ful USRA student will gain skills in:
Electropolymerization, transistor operation and testing, and multidimensional data processing and machine learning.

Dr. David L. Jakeman听 -听 Jakeman Lab Website
david.jakeman@dal.ca
Professor - Cross-appointed from Pharmacy
听
Example project 1. Chemical biology: discovery of new natural products with cytotoxic activity.
Students will learn sterile technique, learn to culture soil bacteria and how to induce secondary metabolite production. They will learn to analyse culture aliquots spectrophotometrically and by LC/MS/MS. Scale-up of cultures and the isolation of the natural products will be performed, providing experience in chromatography and NMR spectroscopy.
Eight-membered ring-containing jadomycins: implications for non-enzymatic natural products biosynthesis. Robertson, A.W.; Martinez-Farina, C.F.; Smithen, D.A.; Yin, H.; Monro, S.; Thompson, A.; McFarland, S.A.; Syvitski, R.T.; Jakeman, D.L., J. Am. Chem. Soc. 2015, 137, 3271鈥�3275. http://pubs.acs.org/doi/abs/10.1021/ja5114672

Example project 2. Chemical biology: synthesis and evaluation of enzyme inhibitors as potential antibacterials.
Students will learn the fundamentals of any of the following: organic synthesis, enzyme kinetics, the basics of chromatography, operation of HPLC instrumentation, PCR, cloning, expression and site-directed mutagenesis.
伪-Fluorophosphonates reveal how a phosphomutase conserves the protein transition state over hexose recognition in its two-step reaction Jin, Y.; Bhattasali, D.; Pellegrini, E.; Forget, S.M.; Baxter, N.J.; Cliff, M.J.; Bowler, M.W.; Jakeman, D.L.; Blackburn, G.M.; Waltho, J.P. Proc. Natl. Acad. Sci USA. 2014, 111, 12384-12389. http://www.pnas.org/content/111/34/12384.long

Dr. Ryan MacDonell听 -听
rymac@dal.ca
Assistant Professor of Chemistry - Cross-appointed with Physics

Theoretical prediction of photochemical reactions
Predicting what happens after a molecule absorbs a photon is one of the most difficult problems in theoretical chemistry. Internal conversion between electronic states occurs in cases where the electronic states are strongly coupled to vibrations of atomic nuclei. During internal conversion, the molecule is funneled between electronic states at geometries where the electronic states are degenerate, known as conical intersection seams. Past work has focused on interpreting photochemical reactions through only minimum-energy points on the conical intersection seam. This project will build on recent work in the MacDonell Group to find and visualize all regions of the seam that are energetically accessible. The goal of the project is to develop methods that work with quantum chemistry software to identify trends in molecules that undergo internal conversion.

The pilipili漫画ful USRA will gain skills in:
Programming with Python, quantum chemistry methods.

Dr.听Mark Obrovac听 -听听
mobrovac@dal.ca
Professor of Chemistry - Cross-appointed with Physics

Metal-Ion Battery Materials Chemistry
The Obrovac lab designs and synthesizes highly engineered materials (nanostructured materials, core/shell particles, metallic glasses, etc.) for lithium-ion, sodium-ion and multivalent metal batteries for use in grid storage and electric vehicles. New metal-ion battery chemistries have the potential to store significantly more energy than conventional lithium-ion battery materials, at similar or even lower cost.

The pilipili漫画ful USRA student will gain skills in:
Materials design, nanostructured materials synthesis, mechanochemical synthesis, mechanofusion, topotactic reactions, electron microscopy, x-ray diffractometry, M枚ssbauer spectroscopy, electrochemical methods, battery assembly and testing, electrolyte characterization.

Dr. Jan K. Rainey听 -听
jan.rainey@dal.ca
Professor - Cross-appointed from Biochemistry & Molecular Biology

The pilipili漫画ful USRA student will gain skills in:
molecular biology based cloning and expression; recombinant protein purification; silk spinning or film casting; characterization of biomaterials by spectroscopy, microscopy, and mechanical testing; functional evaluation of biomaterials.

Dr. Alex Speed听 -听
aspeed@dal.ca
Assistant Professor of Chemistry

Dr.听Mark Stradiotto听 -听 Stradiotto Lab websitemark.stradiotto@dal.ca
Professor of Chemistry

Homogeneous Catalyst Development for Organic Synthesis:
The Stradiotto group has made a number of important discoveries recently in this area, whereby new coordination complexes are designed, synthesized and characterized, and then applied as catalysts. This has led to our now-commercialized "DalPhos" based catalyst complexes that are used in pharmaceutical synthesis. This summer USRA project will involve exploring the way in which such catalysts operate (mechanism) as well as designing and preparing new and increasingly effective catalysts.

The pilipili漫画ful USRA student will gain skills in:
the synthesis of organic and inorganic compounds; air-sensitive glove-box methods; compound purification protocols including column chromatography; and compound detection and characterization methods including gas chromatography and NMR spectroscopy.

Dr. Alison Thompson听 -听
alison.thompson@dal.ca
Professor of Chemistry

Synthesis and Characterization of Pyrroles
This project will involve the preparation of pyrroles with the goal of incorporating these molecules into larger assemblies with potential applications in materials and pharmaceutical science. Undergraduate students will work in a team environment, and will ultimately be responsible for running reactions and characterizing the products.

The pilipili漫画ful USRA student will gain skills in:
synthetic chemistry; isolation procedures such as distillation, chromatography and crystallization; characterization techniques including NMR spectroscopy and mass spectrometry.

Dr. Laura Turculet听 -听
laura.turculet@dal.ca
Associate听Professor of Chemistry

Synthesis and Reactivity of New Transition Metal Pincer Complexes
Research in the Turculet group is focused on the synthesis of new, highly reactive transition metal complexes supported by multidentate 鈥減incer鈥�-type ligands. These molecular pincers are specifically designed to grab a tight hold of the reactive metal center, binding via three sites in order to set up an optimum environment for chemical reactivity. This project will involve the synthesis of new classes of pincer ligands and their corresponding metal complexes. The structure and reactivity of new complexes will be investigated, with particular emphasis on exploring possible applications in catalysis.

The pilipili漫画ful USRA student will gain skills in:
organic and inorganic synthesis; techniques for the manipulation of air-sensitive compounds (glove box, Schlenk line); crystallization; multi-nuclear and variable temperature NMR spectroscopy.

Dr. Alex Veinot
aveinot@uwo.ca
Assistant Professor

1. Surface modification of aluminum using 尾-Diketiminato aluminum complexes
Aluminum is the most abundant metal in the Earth鈥檚 crust and is lightweight, non-toxic, thermally conductive, and easily machined. These properties have resulted in the widespread use of aluminum in transportation, packaging and construction applications. Upon exposure to air, aluminum naturally produces a corrosion-resistant layer of oxide (Al₂O₃) which displays high chemical inertness and electrical resistance. These properties are useful in electronic applications in which Al₂O₃ is frequently used as an insulating dielectric material with a large band gap.

This project will examine the use of readily available 尾-diketiminato aluminum complexes as precursors to form addressable self-assembled monolayers (SAMs) on aluminum and Al₂O₃ surfaces in solution. Unlike current strategies which use chlorosilanes or phosphonates, the properties (e.g. packing density, stability) of the resultant SAMs will be tunable through choice of N-substituents. The resultant thin films are expected to be highly robust due to a combination of strong covalent Al-O bonds with the substrate and the use of a bidentate supporting ligand. Further modification of these SAMs will be explored via on-surface reactions (e.g. deprotonation, S_N2), demonstrating a new class of modular and highly tunable SAMs for aluminum surfaces.

The pilipili漫画ful USRA student will gain skills in:
organic, main group, surface, and materials chemistry.

2. Self-assembled monolayers of N-heterocyclic carbene chalcogenides
Transition metal chalcogenides (TMCs) are an important class of materials with unique optical, mechanical, and thermal properties with applications related (but not limited) to electronics, photovoltaics, and catalysis. TMCs can be prepared by chemical vapour deposition or solution methods, however processes used for fabricating these materials often require high temperatures (>150 掳C) which is undesirable for their sustainable synthesis.

N-heterocyclic carbenes (NHCs) are an important class of ligand with emerging applications in surface science for the preparation of self-assembled monolayers (SAMs). In this preliminary work, NHC chalcogenide adducts (1) will be examined as small molecule precursors for preparing 2D TMC films on coinage metal substrates. Adducts 1 are air-stable and readily available by reaction of the free NHC with a suitable chalcogen source, and readily bind to transition metal elements in molecular chemistry. In this work, SAMs of 1 will be prepared on copper, silver or gold substrates and characterized using X-ray photoelectron spectroscopy (XPS). Annealing experiments will be used to understand the properties of the metal-ligand interface and to evaluate the potential of 1 to form 2D copper, silver or gold chalcogenides.

The pilipili漫画ful USRA student will gain skills in:
organic, main group, transition metal, surface, and materials chemistry

Dr. Peter D. Wentzell听 -听
peter.wentzell@dal.ca
Professor of Chemistry

Chemometrics and Bioinformatics in Analytical Chemistry
The goal of our work is to extract meaningful chemical and biological information from complex chemical measurements using advanced mathematical, statistical and computer-based tools.听 The problems take many forms and include exploration of complex relationships, classification of samples (pattern recognition), prediction of properties (multivariate calibration), and modeling of chemical and biological systems (curve resolution).听 We attempt to develop new tools to address important real-world problems ranging from forensics to food adulteration to biology and medicine.听 This work is well-suited to those who enjoy the challenge of applying math creatively to solve practical problems relevant to chemistry, and is a great fit for those in interdisciplinary programs involving math, statistics or computer science.听 Some typical undergraduate projects include: the application of multivariate curve resolution to study feeding patterns of fish in the Gulf of Alaska; the application of projection pursuit methods to the classification of samples in forensics, agriculture and biology; and the application of chemometric methods in proteomics.

The pilipili漫画ful USRA student will gain skills in:
Multivariate data analysis, computer programming, statistics, chemometrics

Dr. Josef W. Zwanziger听 -听
jzwanzig@dal.ca
Professor and Canada Research Chair - Cross-appointed with Physics

1. Broad-Band Optical Properties of Glass
In this project the student will work towards development of glass with flat stress response over the entire optical spectrum. The work will entail both preparation of glass samples and their measurement under stress in different optical spectrometers available in our laboratory. There may be some opportunity for work with NMR and Mossbauer spectroscopy as well.

The pilipili漫画ful USRA student will gain skills in:
high temperature preparation of optical glass samples and various optical characterization methods (transmission, reflectance, birefringence).

2. Computational studies of solid materials
In this project the student will use first-principles computational methods to study solid materials, particularly their responses to experimental methods also ongoing in the lab, notably NMR, Mossbauer spectroscopy, and optical response. The student will execute existing codes to compute these properties on model systems and also correlate the results with experiment and chemical principles.

The pilipili漫画ful USRA student will gain skills in:
solid-state physics and computational methods, familiarity with programming in Fortran 90 and Python.